Nicotine itself is the substance smokers and vapers (e-cigarette users) crave…puffing on an analog or electronic cigarette is simply the delivery method for this nicotine.
Thousands of deaths each year are attributed to smoking traditional cigarettes, which is why there is some ambiguity on whether the nicotine itself is harmful. Numerous studies have shown that other substances in the cigarette smoke like tar and carcinogens amplify these risks, not the nicotine itself.
The substance nicotine is in fact naturally occurring and is derived from the tobacco plant Nicotiana tabacum and is considered an alkaloid, which is basically a naturally occurring compound comprised mostly of nitrogen. Its chemical formula is C10H14N2.
Nicotine certainly has physical impacts but whether it’s harmful or not is up for debate. Some have claimed that it causes cancer but it is not proven.
What nicotine does do is stimulate the production of dopamine within seconds of being inhaled. Dopamine is a neurotransmitter that regulates emotions and feelings of pleasure. Nicotine’s effects on the brain are similar, albeit to much lesser degree, than cocaine or amphetamines. This fact is why many make the claim that nicotine is as addictive as cocaine and heroin.
Besides these psychological effects, ingesting nicotine also causes increased heart rate and blood pressure and restricts blood flow to the heart. Interestingly, nicotine can act as either a stimulant or a depressant. Nicotine also has the effect of increasing alertness and enhancing mental performance.
While these effects are relatively minor, NICOTINE IS VERY ADDICTIVE
People who are addicted to nicotine do experience withdrawal symptoms when they stop smoking or otherwise ingesting nicotine. Anger, anxiety, depressed mood, difficulty concentrating, increased appetite and cravings for nicotine are very real.
These effects though subside within 3-4 weeks in most people…cravings and hunger though may go on for months.
Nicotine’s addictive nature is largely due to the dose and rapid delivery to the brain when vaping or smoking cigarettes.
So in the end, nicotine is very addictive but it isn’t necessarily too harmful. Other substances in cigarette smoke like tar and carcinogens are largely responsible for health effects connected with smoking. Simply ingesting nicotine, while it has its effects, is relatively harmless.



